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LIPID Ligand Discovery

find lipids ligands that bind membrane readers & drug targets

bird of prey

Ligand discovery & characterization

We offer biophysical instrument access and services for discovery of lipid ligands and small molecule drug lead candidates for membrane-associate proteins using SMALP technology and native nanodiscs.

Sets of polymer-based nanodiscs can be screened and including various lipid combinations that represent bar codes for cellular membranes and organelles.

We offer fee-for service access to our CFI-funded systems including:

We offer access to the latest technologies for biomolecular analysis used to screen and cross validate lipid and drug molecules, measuring their affinities and profiling ligand specificities .

Molscreen was initiated by Michael Overduin and coapplicants with a grant from the John R. Evans Leaders Fund awarded by the Canada Foundation for Innovation (CFI) and Province of Alberta.

Our team welcomes opportunities for collaboration and partnering, and has experience in setting up, running and supporting drug discovery projects focused on a range of emerging and established targets including membrane-associated proteins.

Gator+ BLI system at the University of Alberta

bli

Funded by:

university of alberta canada foundation for innovation alberta innovates