ligand Discovery
find lipid, metabolite peptide, antibody and drug molecule ligands for your target
Ligand discovery & characterization
We offer biophysical instrument access and services for discovery of ligands including lipid and drug molecules for target including soluble proteins and membrane proteins in nanodiscs.
Libraries of molecules can be screened including drug-like compounds, biological signals, glycans, ions, lipids, metabolites, modified amino acids and nucleotides, osmolytes and stabilizers.
We offer open access to CFI-funded systems including:
- GatorBio Biolayer Interferometry 8-channel & 96/384 well microplate system for ligand screening, profiling, affinities and kinetics of small molecules, protein, antibody and nanodisc interactions
- Fluidic Analytics Fluidity One-W for affinity, size, stoichiometry information of macromolecular assemblies including nanodiscs and protein complexes
- Malvern Panalytical MicroCal PEAQ ITC for label-free ligand binding kinetics and stoichiometries
- Malvern Panalytical Zetasizer Ultra for measurement of nanodisc sizes, charges, concentrations and multiangle dynamic light scattering
- NANUC NMR spectrometers: Varian 600 and 500 MHz systems resolve proton, carbon-13, nitrogen-15, phosphorus-31 nuclei of proteins, small molecules, polymers, metabolites
We offer access to the latest technologies for biomolecular analysis used to screen and cross validate ligands, measure affinities and profile specifities of your hit and lead molecule.
Molscreen was initiated by Michael Overduin and coapplicants with a grant from the John R. Evans Leaders Fund awarded by the Canada Foundation for Innovation (CFI) and Province of Alberta.
Our team welcomes opportunities for collaboration and partnering, and has experience in setting up, running and supporting drug discovery projects focused on a range of emerging and established targets including a range of membrane proteins, GTPases, kinases and phosphatases.
Gator+ BLI system at the University of Alberta
